Enhanced Radiation Sensitivity in HPV-Positive Head and Neck Cancer
نویسندگان
چکیده
منابع مشابه
Enhanced radiation sensitivity in HPV-positive head and neck cancer.
Patients with human papillomavirus (HPV+)-associated head and neck cancer (HNC) show significantly improved survival outcome compared with those with HPV-negative (HPV-) tumors. Published data examining this difference offers conflicting results to date. We systematically investigated the radiation sensitivity of all available validated HPV+ HNC cell lines and a series of HPV- HNC cell lines us...
متن کاملMolecular and Cellular Pathobiology Enhanced Radiation Sensitivity in HPV-Positive Head and Neck Cancer
Patients with human papillomavirus (HPVþ)–associated head and neck cancer (HNC) show significantly improved survival outcome compared with those with HPV-negative (HPV ) tumors. Published data examining this difference offers conflicting results to date. We systematically investigated the radiation sensitivity of all available validated HPVþHNC cell lines and a series of HPV HNC cell lines usin...
متن کاملBiological Basis for Increased Sensitivity to Radiation Therapy in HPV-Positive Head and Neck Cancers
Although development of head and neck squamous cell carcinomas (HNSCCs) is commonly linked to the consumption of tobacco and alcohol, a link between human papillomavirus (HPV) infection and a subgroup of head and neck cancers has been established. These HPV-positive tumors represent a distinct biological entity with overexpression of viral oncoproteins E6 and E7. It has been shown in several cl...
متن کاملMonoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro.
BACKGROUND Perillyl alcohol (POH) elicited anticarcinogenic effects in a number of cancer models and pharmacokinetic studies in humans revealed that PA is the major circulating metabolite following POH administration. MATERIALS AND METHODS Effects of PA or POH alone, or in combination with radiation, on human head and neck squamous cell carcinoma cell lines (HNSCC), were investigated using cy...
متن کاملchromosomal sensitivity to ionising radiation in lymphocytes of patients with head and neck cancer
purpose: the aim of this study was to test the in vitro sensitivity of lymphocytes of patients with head and neck cancer against gamma irradiation and also to find out if the frequencies of chromosomal aberrations correlate with side effects of radiotherapy. patients and methods : peripheral blood of 101 patients with head and neck cancer was collected before the onset of radiotherapy, cultured...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2013
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-13-0587